
NE 52-QQ57
CAS No. 1401728-56-0
NE 52-QQ57 ( —— )
产品货号. M21996 CAS No. 1401728-56-0
NE 52-QQ57 是一种选择性口服 GPR4 拮抗剂 (IC50 : 70 nM),具有抗炎活性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1320 | 有现货 |
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10MG | ¥2001 | 有现货 |
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25MG | ¥3362 | 有现货 |
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50MG | ¥4998 | 有现货 |
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100MG | ¥7112 | 有现货 |
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200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称NE 52-QQ57
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述NE 52-QQ57 是一种选择性口服 GPR4 拮抗剂 (IC50 : 70 nM),具有抗炎活性。
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产品描述NE 52-QQ57 is a selective, and orally available antagonist of GPR4(IC50 : 70 nM),with anti-inflammatory activity.
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体外实验NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation (IC50 26.8?nM in HEK293?cells).
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体内实验NE 52-QQ57 (Compound 13) shows a significant anti-inflammatory effect in the rat antigen induced arthritis model after oral administration at 30 mg/kg bid for 20 days.NE 52-QQ57 (30 mg/kg bid po for 4 days) also prevents angiogenesis in the mouse chamber model as well as pain as demonstrated in the rat complete Freund’s adjuvant model. Animal Model:Female FVB mice (8-10 weeks)Dosage:30 mg/kg Administration:Oral, 4 days, bid Result:Treatment at 30 mg/kg p.o. bid starting on day 0, the day of the chamber implantation, showed a statistically significant reduction (46.8±10.6%) of tissue growth by day 4. The blood levels of 13 on day 4 at 2 and 16 h after compound application in this model were 9.03±2.87 and 0.09±0.06 μM.Animal Model:Male Wistar Han rats Dosage:3, 10, and 30 mg/kg Administration:Oral, 20 days, bid Result:Displayed not only higher exposures in the rat AIA but also lower plasma protein binding in rat (95%).
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同义词——
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通路Others
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靶点Other Targets
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受体GPR4
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研究领域——
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适应症——
化学信息
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CAS Number1401728-56-0
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分子量416.52
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分子式C24H28N6O
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纯度>98% (HPLC)
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溶解度DMSO:5mg/ml (12 Mm; Need ultrasonic)
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SMILESCCC1=NN2C(N=C(C)C=C2C)=C1CC1=CC=C(C=C1)C1=NN=C(O1)C1CCNCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Hosford PS, et al. CNS distribution, signalling properties and central effects of G-protein coupled receptor 4. Neuropharmacology. 2018 Aug;138:381-392.
产品手册




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